Aging of the neck is a multifactorial process that results in skin dyspigmentation, laxity, rhytides, loss of the mandibular contour, widening of the cervicomental angle, accumulation of submental fat, volume loss, and prominence of platysmal bands [12]. Thus, rejuvenation of the neck often requires a multimodal approach to address these multiple facets of aging. In a recently published study Doh et al. demonstrated that a single-day combination treatment with microfocused ultrasound with visualization (MFU-V), neuromodulators, and filler injections for neck rejuvenation in Asians is effective as determined by three blinded evaluators [17]. Nevertheless, the aging of the neck (e.g., skin thickness and fat accumulation pattern) differ in Asians and other ethnicities, giving reason to evaluate this multimodal approach in a Caucasian based population. Moreover, quantification of this approach is warranted for more robust conclusions.